My maternal grandmother's ancestors were in Allegheny County, Pennsylvania. I have written about my second great grand uncle, James M. Lysle, who died in Virginia, serving for the 63rd Regiment Pennsylvania Volunteers. I share his picture here again. His youngest brother, George Lysle, my second great-grandfather, was born in 1845, possibly too young to serve, but working in a coal company, perhaps he provided help in the war effort in other ways.
There were a few other Alstons and Lysles (great-uncles and/or distant cousins) who served from Allegheny County, Pennsylvania. The Pennsylvania, Veterans Burial Cards, 1777-1999, at Ancestry.com, is a good resource to determine Civil War service. I do not find my third great grandfather, James Freeland, who died on March 1, 1863, at about age 48, according to his gravestone (see his FindAGrave memorial) or my third great-grandfather, Samuel Hunter, who also died in 1863 at about age 49, in this database, or in Civil War records at Fold3.com, so it appears that they may not have fought, but perhaps served in other ways.
My maternal grandfather's father's family was in Maine (see second great-grandfather Henry Copeland's draft information here). It looks like he was exempted from service.
My maternal grandfather's mother's family was in Chicago. I wrote about what I could find about second great-grandfather Samuel S. Greeley's service (building sewers) here.